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Researchers at Baylor University and Stanford University say they’ve taken an important step toward condensing some of the benefits of exercise into a simple pill.
Researchers, Yong Xu, Ph.D., professor of Pediatrics at Baylor, and Jonathan Long, Ph.D., assistant professor of pathology at Stanford University, said they had identified a molecule produced in the blood during exercise that successfully reduced food intake and food intake in mice. obesity. Baylor College of Medicine.
“Regular exercise has been shown to help with weight loss, appetite regulation, and improved metabolic status, especially for overweight and obese individuals,” Xu said. “If we can understand the mechanisms by which exercise triggers these benefits, we’re one step closer to helping many people improve their health.”
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FILE – Anandi Cade lifts weights at Fitness SF on Fillmore Street in San Francisco, Dec. 29, 2021.
(Scott Strazzante/San Francisco Chronicle via Getty Images)
“We wanted to understand how exercise works at the molecular level in order to be able to reap some of its benefits,” Long added. “For example, older or frail people who can’t get enough exercise may one day benefit from taking drugs that help slow osteoporosis, heart disease, or other conditions.”
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The pair of researchers identified an amino acid called Lac-Phe. According to Baylor, when they gave mice fed a high-fat diet a dose of amino acids, they observed a 50 percent reduction in food intake over the ensuing 12 hours.
The researchers also found that humans, and even racehorses, produce the same amino acids during vigorous physical activity.
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“Our next steps include finding more details about how Lac-Phe mediates its effects in the body, including the brain,” Xu told Baylor. “Our goal is to learn to modulate this motor pathway for therapeutic intervention.”