An exercise-induced metabolite that suppresses eating and obesity

  • Eriksson, KF & Lindgärde, F. Prevention of type 2 (non-insulin-dependent) diabetes mellitus through diet and physical activity. Diabetes 34891–898 (1991).

    CAS Article Google Scholar

  • Reyeski, WJ et al. Lifestyle changes and mobility in obese adults with type 2 diabetes. N. England. J. Medicine. 3661209–1217 (2012).

    CAS Article Google Scholar

  • Stampfer, MJ, Hu, FB, Manson, JE, Rimm, EB & Willett, WC Primary prevention of coronary heart disease in women through diet and lifestyle. N. England. J. Medicine. 34316–22 (2000).

    CAS Article Google Scholar

  • Helmrich, SP, Ragland, DR, Leung, RW & Paffenbarger, RS Physical activity and reduction in non-insulin-dependent diabetes mellitus. N. England. J. Medicine. 325147–152 (1991).

    CAS Article Google Scholar

  • Rawshani, A. et al. Risk factors, mortality, and cardiovascular outcomes in patients with type 2 diabetes. N. England. J. Medicine. 379633–644 (2018).

    Article Google Scholar

  • Sanford, JA, et al. Molecular Sensors for the Physical Activity Alliance (MoTrPAC): Mapping Dynamic Responses to Movement. cell 1811464–1474 (2020).

    CAS Article Google Scholar

  • Contrepois, K. et al. Molecular orchestration of acute exercise. cell 1811112–1130.e16 (2020).

    CAS Article Google Scholar

  • Morville, T., Sahl, RE, Moritz, T., Helge, JW & Clemmensen, C. Plasma metabolome analysis of resistance and endurance exercise in humans. cell representation 33108554 (2020).

    CAS Article Google Scholar

  • Lewis, GD et al. Metabolic characterization of exercise in human plasma. science. translate. medicine. 233ra37 (2010).

    Article Google Scholar

  • Roberts, LD et al. β-Aminoisobutyric acid induces white fat browning and hepatic β-oxidation and is inversely associated with cardiometabolic risk factors. cellular metabolites. 1996–108 (2014).

    CAS Article Google Scholar

  • Stanford, KI et al. 12,13-diHOME: an exercise-induced lipid factor that increases fatty acid uptake in skeletal muscle. cellular metabolites. 271111–1120.e3 (2018).

    CAS Article Google Scholar

  • Reddy, A. et al. pH-gated succinate secretion regulates muscle remodeling in response to exercise. cell 18362–75.e17 (2020).

    CAS Article Google Scholar

  • Yuan, Y. et al. Exercise-induced alpha-ketoglutarate stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation. EMBO J. 39e103304 (2020).

    CAS Article Google Scholar

  • Klein, AB et al. Pharmacological but not physiological GDF15 inhibits motivation to eat and exercise. Nat. comminicate. 121041 (2021).

    ADS CAS Article Google Scholar

  • Green, HJ & Fraser, IG Differential effects of exercise intensity on serum uric acid concentrations. medicine. science. Physical exercise. 2055–59 (1988).

    CAS Article Google Scholar

  • Schranner, D., Kastenmüller, G., Schönfelder, M., Römisch-Margl, W. & Wackerhage, H. Changes in human metabolite concentrations after a single exercise session: a systematic review of exercise metabolomics studies. sports. medicine.Open 611 (2020).

    Article Google Scholar

  • Gaffney, B. & Cunningham, EP Estimation of Genetic Trends in Racing Performance in Thoroughbred Horses. nature 332722–724 (1988).

    ADS CAS Article Google Scholar

  • Hagenfeldt, L. & Naglo, AS Neoconjugated urinary metabolites in intermediate maple syrup diabetes. clinical. Chim.Journal 16977-83 (1987).

    CAS Article Google Scholar

  • Bottesini, C., Tedeschi, T., Dossena, A. & Sforza, S. Enzymatic production and degradation of cheese-derived non-proteolytic aminoacyl derivatives. amino acid 46441–447 (2014).

    CAS Article Google Scholar

  • Sgarbi, E. et al. Microbial sources of non-proteolytic aminoacyl derivatives in long-ripened cheese. food microbes. 35116–120 (2013).

    CAS Article Google Scholar

  • Jensen, RS et al. n-Lactoylamino acids are ubiquitous metabolites derived from CNDP2-mediated reverse proteolysis of lactate and amino acids. process. National Academy of Sciences. science.U.S. 1126601–6606 (2015).

    ADS CAS Article Google Scholar

  • Sharma, R. et al. Circulating markers of NADH reducing stress correlate with mitochondrial disease severity. J. Clin. invest. 131e136055 (2021).

    CAS Article Google Scholar

  • Tabula Muris Consortium. Single-cell transcriptomics of 20 mouse organs creates a whiteboard. nature 562367–372 (2018).

    ADS CAS Article Google Scholar

  • Locke, AE et al. Genetic studies of body mass index provide new insights into obesity biology. nature 518197–206 (2015).

    CAS Article Google Scholar

  • Ringholm, S. et al. PGC-1α is required for exercise- and exercise-training-induced upregulation of UCP1 in mouse white adipose tissue. PLoS One 8e64123 (2013).

    ADS Article Google Scholar

  • Kim, YJ, Kim, HJ, Lee, WJ & Seong, JK Comparison of the metabolic effects of treadmill and wheel running exercise in a mouse model. laboratory. animation. reservoir. 361-8 (2020).

    Article Google Scholar

  • DeWolfe, CJF et al. Vesicles from human and mouse erythrocytes are transported by cGMP. FEBS J. 274439–450 (2007).

    Article Google Scholar

  • Smith, CA et al. XCMS: Process mass spectrometry data for metabolite analysis using nonlinear peak alignment, matching, and identification. anus. Chemical. 78779–787 (2006).

    CAS Article Google Scholar

  • Agudello, LZ et al. Skeletal muscle PGC-1α1 regulates kynurenine metabolism and mediates resilience to stress-induced depression. cell 15933–45 (2014).

    CAS Article Google Scholar

  • Coxon, JP, et al. GABA concentrations in the sensorimotor cortex and their relationship to lactate levels after high-intensity exercise. J. Physiology. 596691–702 (2018).

    CAS Article Google Scholar

  • Human energy needs: report of the joint FAO/WHO/UNU expert consultation (FAO, WHO, UNU, 2005).

  • Sanjana, NE, Shalem, O. & Zhang, F. Improved vector and genome-wide libraries for CRISPR screening. Nat.method 11783–784 (2014).

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